Ethylmorpholine → HCID 178502932, compound

Temperature

0 °C

1.06 g of L-leucyl-L-alanine ethyl ester hydrochloride and 1.46 g of 2(RS)-[[(RS)-(methoxy)(phthalimidomethyl)phosphinyl]methyl]-4-methylvaleric acid, prepared as described in Example 1(A)(iii), were dissolved in 12 ml of dimethylformamide. The solution was cooled to 0° C. Thereafter, 1.08 g of hydroxybenzotriazole and 0.46 g of N-ethylmorpholine were added and, after all of the solids had dissolved, 0.88 g of N,N'-dicyclohexylcarbodiimide was added. The mixture was stirred at room temperature for 18 hours. The solvent was then removed by evaporation. The residue was triturated with 50 ml of ethyl acetate and the mixture was filtered in order to remove dicyclohexylurea. The filtrate was washed twice with 50 ml of saturated sodium hydrogen carbonate solution each time, dried over anhydrous sodium sulfate and evaporated to give a yellow gum. This gum was purified by flash chromatography using ethyl acetate for the elution. There were obtained 1.06 g of [(R or S)-2-[[(S)-1-[[(S)-1-(ethoxycarbonyl)ethyl]carbamoyl]-3-methyl-butyl]carbamoyl]-4-methylpentyl](phthalimidomethyl)phosphinic acid methyl ester hydrochloride in the form of a white foam.

1. dissolutionafter all of the solids had dissolved
2. customThe solvent was then removed by evaporation
3. customThe residue was triturated with 50 ml of ethyl acetate
4. filtrationthe mixture was filtered in order
5. customto remove dicyclohexylurea
6. washThe filtrate was washed twice with 50 ml of saturated sodium hydrogen carbonate solution each time
7. dry with materialdried over anhydrous sodium sulfate
8. customevaporated
9. customto give a yellow gum
10. customThis gum was purified by flash chromatography
11. washfor the elution

ORD record

ord-29bf10f365ba4e848ca8fe5cb47dbd9d

Source dataset

uspto-grants-1991_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05006651