反应详情

To an anhydrous tetrahydrofuran solution containing 2.4 g of 4-[4-(2-tetrahydropyranyloxy)phenyl]-3-butynylacetate was added 1 g of lithium aluminium hydride and the mixture was refluxed for 12 hours. After the reaction was finished, a saturated sodium sulfate aqueous solution was slowly added to the reaction mixture, and the precipitates formed were removed by filtration, then the filtrate was dried with anhydrous sodium sulfate, and concentrated to dryness. The residue thus obtained was purified by means of a silica gel column chromatography to yield 2 g of 4-[(2-tetrahydropyranyloxy)phenyl]-3(E)-butenylalcohol as in the form of colorless oily substance.

1. temperaturethe mixture was refluxed for 12 hours
2. customthe precipitates formed
3. customwere removed by filtration
4. dry with materialthe filtrate was dried with anhydrous sodium sulfate
5. concentrationconcentrated to dryness
6. customThe residue thus obtained
7. customwas purified by means of a silica gel column chromatography