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HRID1091445

反应详情

EQUATION

反应方程式

HRID 1091445 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OC(=O)C[C@H](N)C(O)COc1c(F)c(F)cc(F)c1F
HCID44604220

1,1-Dimethylethyl (4ξ)-3-amino-2,3-dideoxy-5-O-(2,3,5,6-tetrafluorophenyl)-D-glycero-pentonate

C15H19F4NO4

结构：CC[C@@H](C(=O)O)n1ccc2ccc(C(F)(F)F)cc2c1=O
HCID66593818

未命名化合物

PRODUCTS

生成物

1
结构：CC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)COc1c(F)c(F)cc(F)c1F)n1ccc2ccc(C(F)(F)F)cc2c1=O
HCID10257542

未命名化合物

PROCEDURE

实验过程

This compound was prepared using (S)-2-(7-trifluoromethyl-1-oxo-1H-isoquinolin-2-yl)-butyric acid (prepared as described in methods A-E, see example 2) and (3S)-3-amino-4-hydroxy-5-(2,3,5,6-tetrafluoro-phenoxy)-pentanoic acid tert-butyl ester (prepared as described in methods N-P) using procedures similar to those described in methods F, G and E. The product was isolated as a white solid (90% last step). IR (solid) 1791.6, 1649.5, 1516.8, 1493.1, 1322.5 cm−1; 1H NMR (400 MHz, d6-DMSO) δ 0.85 (3H, t), 1.90-2.20 (2H, 2×m), 2.50-2.90 (2H, 2×m), 4.70 (1H, m), 5.25 (2H, dd), 5.45 (1H, m), 6.80 (1H, d), 7.65 (1H, m), 7.70 (1H, d), 7.95 (1H, d), 8.05 (1H, d), 8.45 (1H, s), 9.00 (1H, d) ppm; 19F NMR (376 MHz, d6-DMSO) (proton decoupled) δ −56.60, −70.15, −136.38, −152.08.

WORKUP

后处理

  1. customThis compound was prepared
  2. customThe product was isolated as a white solid (90% last step)