反应详情

3-bromo-4-chloroisobenzofuran-1(3H)-one (100) (14 g, 56.57 mmol) and triphenylphosphine (14.84 g, 56.57 mmol) were dissolved THF (200 mL) and heated at reflux for 2 hours. The reaction was cooled and filtered, the filtrate was evaporated to the desired compound as a yellow gum (22.5 g, 78% yield); 1H NMR (400.132 MHz, CDCl3) δ 7.54-7.51 (2H, m), 7.65-7.59 (7H, m), 7.79-7.74 (3H, m), 8.07-8.02 (6H, m), 10.41 (1H, s); m/z (LC-MS, ESI+), RT=2.09 (M+H not detected).

1. temperatureheated
2. temperatureat reflux for 2 hours
3. temperatureThe reaction was cooled
4. filtrationfiltered