反应详情

In analogy to example 1, (3,4-dimethyl-phenyl)-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-amine (250 mg, 0.85 mmol, prepared as per example 1, step 3) and tert-butoxycarbonylamino-(4-fluoro-phenyl)-acetic acid (343 mg, 1.27 mmol, commercially available) were coupled together and resolved by chromatography on a chiral columnto afford the title compound (48 mg, 13%) as a pale yellow oil which crystallized upon standing MS m/e: 446.2 [M+H]+.