反应详情

A solution of 3-p-tolylprop-2-yn-1-al (4.69 g; 32.5 mmol; 1 eq) in THF (40 mL) was added to a solution of allylmagnesium bromide (49 mL; 1M in Et20, 1.5 eq) at 0° C. over 25 minutes. Stirring was continued for an additional 2 h, and the reaction was carefully quenched with water (50 mL) at 0° C. MTBE (100 mL) was added, the layers were stirred, and then allowed to separate. The aqueous phase was re-extracted with MTBE (50 mL) and the combined organic layers were dried over sodium sulfate and filtered. The filtrate was concentrated using a rotary evaporator, and purification of the residue by flash chromatography (4:1→2:1 heptane/EtOAc) afforded the desired homoallylic alcohol (4.9 g; 26.3 mmol; 81%). 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 2.34 ((s, 3 H)) 2.56 (t, 2 H) 4.64 (t, 1H) 5.19-5.26 (m, 2H) 5.88-5.99 (m, 1H) 7.10 (d, 2H) 7.31 (d, 2H).

1. customthe reaction was carefully quenched with water (50 mL) at 0° C
2. additionMTBE (100 mL) was added
3. stirringthe layers were stirred
4. customto separate
5. extractionThe aqueous phase was re-extracted with MTBE (50 mL)
6. dry with materialthe combined organic layers were dried over sodium sulfate
7. filtrationfiltered
8. concentrationThe filtrate was concentrated
9. customa rotary evaporator, and purification of the residue by flash chromatography (4:1→2:1 heptane/EtOAc)