反应详情

Aqueous 5 N sodium hydroxide solution (0.28 mL, 1.40 mmol) was added to a methanol (2.3 mL) solution of methyl 4-(benzo[b]thiophen-2-yl)benzoate (124 mg, 0.462 mmol), and refluxed for 3 hours. After left cooled, 5 N hydrochloric acid (0.28 mL, 1.40 mmol) was added to the reaction mixture, and concentrated under reduced pressure. 20% methanol/THF was added to the residue, the mixture was filtered, and the filtrate was concentrated under reduced pressure. Diethyl ether was added to the residue, the insoluble matter was taken out through filtration, and dried to obtain the title compound as a pale yellow solid.

1. temperaturerefluxed for 3 hours
2. waitAfter left
3. temperaturecooled
4. concentrationconcentrated under reduced pressure
5. addition20% methanol/THF was added to the residue
6. filtrationthe mixture was filtered
7. concentrationthe filtrate was concentrated under reduced pressure
8. additionDiethyl ether was added to the residue
9. filtrationthe insoluble matter was taken out through filtration
10. customdried