2-Amino-4-methylthiazole → 2-hydroxy-N-(4-methyl-1,3-thiazol-2-yl)hexanamide

HRID 1098076Notes

Reaction equation

HRID 1098076 reaction equation
[Si]([O:8][CH:9]([CH2:15][CH2:16][CH2:17][CH3:18])[C:10]([O:12]CC)=O)(C(C)(C)C)(C)C.[NH2:19][C:20]1[S:21][CH:22]=[C:23]([CH3:25])[N:24]=1>>[OH:8][CH:9]([CH2:15][CH2:16][CH2:17][CH3:18])[C:10]([NH:19][C:20]1[S:21][CH:22]=[C:23]([CH3:25])[N:24]=1)=[O:12]

Participants

3

Reactant 2

HCID 741432-Amino-4-methylthiazoleHCID 57438620Ethyl 2-{[tert-butyl(dimethyl)silyl]oxy}hexanoate

Product 1

HCID 574386222-hydroxy-N-(4-methyl-1,3-thiazol-2-yl)hexanamide

Procedure

The title compound was prepared in a manner similar to that described for Intermediate A3, starting from ethyl 2-{[tert-butyl(dimethyl)silyl]oxy}hexanoate and 2-amino-4-methylthiazole, 1H NMR (300 MHz, CDCl3) δ 10.30 (br s, 1H), 6.54 (s, 1H), 5.12 (br s, 1H), 4.41 (m, 1H), 2.35 (s, 3H), 2.00 (m, 1H), 1.76 (m, 1H), 1.48 (m, 2H), 1.39 (m, 2H), 0.92 (t, 3H).

Sources & evidence

ORD record
ord-656e76fe4ede46aaa5722addce6da2dc
Source dataset
uspto-grants-2012_03
Patent number
US08143263B2

Reaction notes

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