Diethyl Malonate → HCID 57438628, compound

HRID 1098086Notes

Reaction equation

HRID 1098086 reaction equation
[C:1]([O:9][CH2:10]C)(=O)[CH2:2][C:3]([O:5]CC)=O.[CH3:12][O:13]CCBr.[NH2:17][C:18]1[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][N:19]=1>>[OH:5][CH:3]([CH2:2][CH2:1][O:9][CH3:10])[C:12]([NH:17][C:18]1[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][N:19]=1)=[O:13]

Participants

4

Reactant 3

HCID 7761Diethyl MalonateHCID 153482-Amino-5-methylpyridineHCID 809722-Bromoethyl methyl ether

Product 1

HCID 57438628HCID 57438628, compound

Procedure

The title compound was prepared in a manner similar to that described for Intermediate A16 and Intermediate A2 (Step 2-Step 3) starting from diethyl malonate, 2-bromoethyl methyl ether and 2-amino-5-picoline, 1H NMR (300 MHz, CDCl3) δ 9.24 (br s, 1H), 8.14 (m, 2H), 7.52 (dd, 1H), 4.48 (br s, 1H), 4.39 (m, 1H), 3.69 (m, 2H), 3.39 (s, 3H), 2.25 (m, 4H), 2.09 (m, 1H).

Sources & evidence

ORD record
ord-18942a8ddedb497aa11c1cd81af09eea
Source dataset
uspto-grants-2012_03
Patent number
US08143263B2

Reaction notes

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