5-Methylpyrazin-2-amine → HCID 57504594, compound

HRID 1098109Notes

Reaction equation

HRID 1098109 reaction equation
[Si:1]([O:8][C@@H:9]([CH2:13][O:14][CH:15]([CH3:17])[CH3:16])[C:10]([OH:12])=O)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[CH3:18][C:19]1[N:20]=[CH:21][C:22]([NH2:25])=[N:23][CH:24]=1>>[Si:1]([O:8][C@@H:9]([CH2:13][O:14][CH:15]([CH3:17])[CH3:16])[C:10]([NH:25][C:22]1[CH:21]=[N:20][C:19]([CH3:18])=[CH:24][N:23]=1)=[O:12])([C:4]([CH3:5])([CH3:6])[CH3:7])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 3132155-Methylpyrazin-2-amineHCID 57504592HCID 57504592, compound

Product 1

HCID 57504594HCID 57504594, compound

Procedure

C8a was prepared in an analogous fashion to C4d from (S)-2-(tert-butyldimethylsilyloxy)-3-isopropoxypropanoic acid C7c and 5-methylpyrazin-2-amine. 1H NMR (400 MHz, CDCl3) δ 0.20 (3H, s), 0.21 (3H, s), 1.0 (9H, s), 1.14 (3H, d), 1.17 (3H, d), 2.54 (3H, s), 3.61-3.65 (2H, m), 3.77-3.80 (1H, m), 4.40 (1H, dd), 8.14 (1H, d), 9.01 (1H, s), 9.43 (1H, d)

Sources & evidence

ORD record
ord-a6dcb33a9af441adad09ad020e3d1b4d
Source dataset
uspto-grants-2012_03
Patent number
US08143263B2

Reaction notes

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