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HRID1098187

反应详情

EQUATION

反应方程式

HRID 1098187 的结构方程式

REACTANTS

反应物

2
结构：Clc1ccccc1-n1ncc2c(Cl)ncnc21
HCID11265570

4-CHLORO-1-(2-CHLOROPHENYL)-1H-PYRAZOLO[3,4-D]PYRIMIDINE

C11H6Cl2N4

2 次

结构：COC(=O)[C@@H](O)COCCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C
HCID59279512

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@H](COCCO[Si](c1ccccc1)(c1ccccc1)C(C)(C)C)Oc1ncnc2c1cnn2-c1ccccc1Cl
HCID57504664

Methyl (2S)-3-[2-(tert-butyl-diphenylsilyl)oxyethoxy]-2-[1-(2-chlorophenyl)pyrazolo[4,5-e]pyrimidin-4-yl]oxypropanoate

C33H35ClN4O5Si

PROCEDURE

实验过程

Prepared according to the method for Intermediate AE2 from (S)-methyl 3-(2-(tert-butyldiphenylsilyloxy)ethoxy)-2-hydroxypropanoate (Intermediate AB3) and 4-chloro-1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidine (Intermediate B1). 1H NMR (400 MHz, DMSO) δ 0.94 (9H, s), 3.56-3.75 (4H, m), 3.68 (3H, s), 3.90-4.09 (2H, m), 5.80-5.85 (1H, m), 7.29-7.43 (6H, m), 7.50-7.67 (7H, m), 7.67-7.74 (1H, m), 8.43 (1H, s), 8.52 (1H, s); m/z (ESI+) (M+H)+=631; HPLC tR=3.38 min.

WORKUP

后处理

  1. customPrepared