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HRID1099399

反应详情

EQUATION

反应方程式

HRID 1099399 的结构方程式

REACTANTS

反应物

2
结构：O=S(=O)(Oc1cccc2c1C[C@H](N(Cc1ccccc1)Cc1ccccc1)CO2)C(F)(F)F
HCID25053925

未命名化合物

结构：Cc1cnccc1B(O)O
HCID44754762

(3-Methylpyridin-4-yl)boronic acid

C6H8BNO2

PRODUCTS

生成物

1
结构：Cc1cnccc1-c1cccc2c1C[C@H](N(Cc1ccccc1)Cc1ccccc1)CO2
HCID25114479

未命名化合物

收率 76%

PROCEDURE

实验过程

The title compound was synthesized as described for Intermediate example I-2 in 76% yield, starting from 3-methylpyridine-4-boronic acid and (3S)-3-(dibenzylamino)-3,4-dihydro-2H-chromen-5-yl trifluoromethanesulfonate; 1H NMR (400 MHz, DMSO-d6) δ ppm 8.54 (d, 1 H), 8.46 (dd, 1 H), 7.25-7.32 (m, 8 H), 7.05-7.24 (m, 4 H), 6.76-6.83 (m, 1 H), 6.59-6.64 (m, 1 H), 4.26-4.34 (m, 1 H), 4.04-4.13 (m, 1 H), 3.55-3.68 (m, 4 H), 2.93-3.07 (m, 1 H), 2.34-2.43 (m, 1 H), 2.08-2.22 (m, 1 H), 1.92-2.02 (m, 3 H); MS (ESI) m/z 421[M+H+].