反应详情

The title compound was synthesized as described for Intermediate I-28 in 66% yield starting from (3S)-N,N-dibenzyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)chroman -3-amine and 5-bromo-2-methoxy-N-methylnicotinamide; 1H NMR (400 MHz, DMSO-d6) δ ppm 8.33 (q, 1 H), 8.29 (d, 1 H), 8.06 (d, 1 H), 7.24-7.32 (m, 8 H), 7.11-7.21 (m, 3 H), 6.71-6.82 (m, 2 H), 4.26-4.38 (m, 1 H), 4.04 (s, 3 H), 4.01-4.11 (m, 1 H), 3.57-3.73 (m, 4 H), 2.87-3.09 (m, 2 H), 2.84 (d, 3 H), 2.46-2.54 (m, 1 H, obscured by DMSO); MS (ESI) m/z 494[M+H+].