HRID1099416

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7170095

2-Chloro-6-methylpyrazine

C5H5ClN2

结构：CC1(C)OB(c2cccc3c2C[C@H](N(Cc2ccccc2)Cc2ccccc2)CO3)OC1(C)C

HCID25114260

未命名化合物

PRODUCTS

生成物

结构：Cc1cncc(-c2cccc3c2C[C@H](N(Cc2ccccc2)Cc2ccccc2)CO3)n1

HCID25115599

未命名化合物

收率 83%

PROCEDURE

实验过程

The title compound was synthesized as described for Intermediate example I-28 in 83% yield starting from (S)-N,N-dibenzyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)chroman-3-amine and 2-chloro-6-methylpyrazine (1.1 equiv); 1H NMR (400 MHz, DMSO-d6) δ ppm 8.59 (s, 1 H), 8.54-8.56 (m, 1 H), 7.24-7.34 (m, 8 H), 7.16-7.22 (m, 3 H), 6.99 (dd, 1 H), 6.86 (dd, 1 H), 4.31-4.37 (m, 1 H), 4.07 (t, 1 H), 3.64-3.73 (m, 4 H), 3.12-3.21 (m, 1 H), 2.92-3.02 (m, 1 H), 2.64-2.73 (m, 1 H), 2.55 (s, 3 H); MS (APPI/APCI) m/z 422[M+H+].