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HRID1099420

反应详情

EQUATION

反应方程式

HRID 1099420 的结构方程式

REACTANTS

反应物

2
结构：Brc1ccnnc1
HCID17888927

4-Bromopyridazine

C4H3BrN2

结构：OB(O)c1cccc2c1C[C@H](N(Cc1ccccc1)Cc1ccccc1)CC2
HCID59354908

未命名化合物

PRODUCTS

生成物

1
结构：c1ccc(CN(Cc2ccccc2)[C@@H]2CCc3cccc(-c4ccnnc4)c3C2)cc1
HCID25116057

未命名化合物

收率 45%

PROCEDURE

实验过程

The title compound was synthesized as described for Intermediate example I-48 in 45% yield starting from [(7R)-7-(dibenzylamino)-5,6,7,8-tetrahydronaphthalen-1-yl]boronic acid and 4-bromopyridazine (1 equiv): 1H NMR (400 MHz, CDCl3) δ ppm 9.24 (dd, 1 H), 9.17 (dd, 1 H), 7.31-7.36 (m, 5 H), 7.25-7.30 (m, 4 H), 7.15-7.24 (m, 4 H), 7.00 (dd, 1 H), 3.59-3.70 (m, 4 H), 2.92-3.08 (m, 2 H), 2.69-2.89 (m, 2 H), 2.51-2.62 (m, 1 H), 2.13-2.25 (m, 1 H), 1.71-1.86 (m, 1 H); MS (ESI) m/z 406[M+H+].