反应详情

This was prepared in an identical manner to the compound described in Example 1 using 2-hydroxy-2-(2-fluorophenyl) ethanamine (1.55 g) and 4-{(E)-2-carbomethoxyethenyl}phenylpropan-2-one (2.18 g). Elution with 1% methanolchloroform on Kieselgel 60 gave the title compound (1.2 g) m.p. 111°-116° C. (benzene-heptane) as an ~40:60 mixture of diastereoisomers. τ(CDCl3) 8.95 (3H, d, J=6 Hz), 6.85-7.7 (7H, m, 2H disappears with D2O), 6.25 (3H, s), 5.1 (1H, m), 3.6 (1H, d, J=16 Hz), 2.5-3.2 (8H, m), 2.35 (1H, d, J=16 Hz).

1. customThis was prepared in an identical manner to the compound
2. washElution with 1% methanolchloroform on Kieselgel 60