反应详情

5-(3,4-Dimethoxyphenyl)cyclohexan-1,3-dione (31.8 g) was suspended in ethanol (500 ml), and concentrated hydrochloric acid (20 ml) was added prior to reflux for 3 hours. After the reaction solvent was concentrated under reduced pressure, it was dissolved in chloroform and washed with saturated sodium bicarbonate water. After drying with anhydrous magnesium sulfate, the solvent was concentrated under reduced pressure producing crude crystals which were then washed with diethyl ether to give 10.3 g of 5-(3,4-dimethoxyphenyl)-3-ethoxy-2-cyclohexen-1-one (29.1%).

1. temperatureto reflux for 3 hours
2. concentrationAfter the reaction solvent was concentrated under reduced pressure, it
3. dissolutionwas dissolved in chloroform
4. washwashed with saturated sodium bicarbonate water
5. dry with materialAfter drying with anhydrous magnesium sulfate
6. concentrationthe solvent was concentrated under reduced pressure
7. customproducing crude crystals which
8. washwere then washed with diethyl ether