反应详情

Ethyl 3-(3-aminocyclohexyl)phenoxyacetate (8.47 g) was dissolved in ethanol (50 ml), and (R)-3-chlorostyrene oxide (4.72 g) was added prior to heating to reflux for 7.5 hours. After allowing the mixture to cool, the solvent was concentrated under reduced pressure to obtain an oily substance which was then separated and purified by silica gel column chromatography (n-hexane:ethyl acetate=1:5), to give 8.15 g of (1R)-1-(3-chlorophenyl)-2-[3-(3-ethoxycarbonylmethoxyphenyl) cyclohexylamino]ethanol (trans-H) (compound of Example 11) as an oily substance (61.8% yield).

1. temperatureto heating
2. temperatureto reflux for 7.5 hours
3. temperatureto cool
4. concentrationthe solvent was concentrated under reduced pressure
5. customto obtain an oily substance which
6. customwas then separated
7. custompurified by silica gel column chromatography (n-hexane:ethyl acetate=1:5)