1,2-Difluoro-4-[4-(methoxymethylene)cyclohexyl]benzene → HCID 178520926, compound

HRID 1109691Notes

Reaction equation

HRID 1109691 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH2:13][CH2:12][C:11](=[CH:14][O:15]C)[CH2:10][CH2:9]2)=[CH:4][C:3]=1[F:17]>O1CCCC1>[F:17][C:3]1[CH:4]=[C:5]([C@H:8]2[CH2:9][CH2:10][C@H:11]([CH:14]=[O:15])[CH2:12][CH2:13]2)[CH:6]=[CH:7][C:2]=1[F:1]

Participants

3

Reactant 1

HCID 190192361,2-Difluoro-4-[4-(methoxymethylene)cyclohexyl]benzene

Product 1

HCID 178520926HCID 178520926, compoundYield 91.1%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
0 °C

Procedure

A solution of 5.6 g of 1,2-difluoro-4-[4-(methoxymethylidene)cyclohexyl]benzene in 125 ml of tetrahydrofuran/2N hydrochloric acid (vol. 4:1) was heated to 90° C. for 1.25 hours. The reaction mixture was subsequently poured on to ice-water and extracted with diethyl ether. The ether phase was washed neutral with 50 ml of semi-saturated sodium hydrogen carbonate solution and with two 50 ml portions of water, dried over sodium sulphate and concentrated. A solution of the resulting crude trans/cis mixture (5.1 g) in 25 ml of methanol was added dropwise in an inert gas atmosphere at 0°-3° C. within 5 minutes to 70 ml of 0.1N methanolic potassium hydroxide solution. The reaction mixture was stirred at 0° C. for 1 hour, then poured on to 200 ml of ice-water and extracted with diethyl ether. The ether phases were washed neutral with water, dried over sodium sulphate and concentrated. There were obtained 4.8 g of trans-4-(3,4-difluorophenyl)cyclohexanecarboxaldehyde (cis content 5.7%).

Workup

  1. extractionextracted with diethyl ether
  2. washThe ether phase was washed neutral with 50 ml of semi-saturated sodium hydrogen carbonate solution and with two 50 ml portions of water
  3. dry with materialdried over sodium sulphate
  4. concentrationconcentrated
  5. additionA solution of the resulting crude trans/cis mixture (5.1 g) in 25 ml of methanol was added dropwise in an inert gas atmosphere at 0°-3° C. within 5 minutes to 70 ml of 0.1N methanolic potassium hydroxide solution
  6. additionpoured on to 200 ml of ice-water
  7. extractionextracted with diethyl ether
  8. washThe ether phases were washed neutral with water
  9. dry with materialdried over sodium sulphate
  10. concentrationconcentrated

Sources & evidence

ORD record
ord-2c67690a635042e19494fe00c82bdab5
Source dataset
uspto-grants-1994_06
Patent number
US05322638

Reaction notes

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