Sulfuric Acid → HCID 178444489, compound

HRID 1109697Notes

Reaction equation

HRID 1109697 reaction equation
[CH:1](/[C@H:6]1[CH2:11][CH2:10][C@H:9]([CH:12]([C:16](O)=[O:17])[C:13](O)=[O:14])[CH2:8][CH2:7]1)=[CH:2]\[CH2:3][CH2:4][CH3:5].[H-].[Al+3].[Li+].[H-].[H-].[H-].S(=O)(=O)(O)O>C(OCC)C>[CH:1](/[C@H:6]1[CH2:7][CH2:8][C@H:9]([CH:12]([CH2:13][OH:14])[CH2:16][OH:17])[CH2:10][CH2:11]1)=[CH:2]\[CH2:3][CH2:4][CH3:5]

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 21226445Aluminium lithium hydrideHCID 178444492HCID 178444492, compound

Product 1

HCID 178444489HCID 178444489, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

A solution of 28.6 g of [trans-4-(1E-pentenyl)cyclohexyl]malonic acid in 150 ml of absolute diethyl ether is added dropwise in an inert gas atmosphere within 1 hr. to a suspension of 8.6 g of lithium aluminium hydride in 250 ml of absolute diethyl ether in such a manner that the mixture does not boil too strongly. The mixture is heated to boiling for a further 4 hours and then there are cautiously added dropwise thereto 15 ml of ice-cold water and thereafter 250 ml of 25 percent (v/v) sulphuric acid until the aqueous phase thickens to a grey sludge. The ether phase is decanted and the residue is extracted with four 200 ml portions of diethyl ether. The combined ether phase is washed once with 25 ml of 25 percent sulphuric acid, with two 25 ml portions of saturated sodium hydrogen carbonate solution and with two 25 ml portions of saturated sodium chloride solution, then dried over sodium sulphate and concentrated. Fractional distillation of the residue in a high vacuum gives pure 2-[trans-4-(1E-pentenyl)cyclohexyl]-1,3-propanediol.

Workup

  1. temperatureThe mixture is heated
  2. additionthere are cautiously added dropwise
  3. customThe ether phase is decanted
  4. extractionthe residue is extracted with four 200 ml portions of diethyl ether
  5. washThe combined ether phase is washed once with 25 ml of 25 percent sulphuric acid, with two 25 ml portions of saturated sodium hydrogen carbonate solution and with two 25 ml portions of saturated sodium chloride solution
  6. dry with materialdried over sodium sulphate
  7. concentrationconcentrated
  8. distillationFractional distillation of the residue in a high vacuum

Sources & evidence

ORD record
ord-5a1679898885478b9019e03bf4b12e08
Source dataset
uspto-grants-1994_06
Patent number
US05322638

Reaction notes

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