6-(2-Hydroxy-3-methoxypropyl)-9-methoxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione → HCID 21980594, compound

HRID 11126Notes

Reaction equation

HRID 11126 reaction equation
[OH:1][CH:2]([CH2:30][O:31]C)[CH2:3][N:4]1[C:16]2[CH:15]=[C:14]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:13]3[C:23](=[O:27])[NH:24][C:25](=[O:26])[C:12]=3[C:11]=2[C:10]2[CH:9]=[C:8]([O:28]C)[CH:7]=[CH:6][C:5]1=2>C(OCC)(=O)C.CCCCCC>[OH:1][CH:2]([CH2:30][OH:31])[CH2:3][N:4]1[C:16]2[CH:15]=[C:14]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[C:13]3[C:23](=[O:27])[NH:24][C:25](=[O:26])[C:12]=3[C:11]=2[C:10]2[CH:9]=[C:8]([OH:28])[CH:7]=[CH:6][C:5]1=2

Participants

3

Reactant 1

HCID 219803456-(2-Hydroxy-3-methoxypropyl)-9-methoxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione

Product 1

HCID 21980594HCID 21980594, compoundYield 31.6%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Demethylation of alcohol (225) (96 mg, 0.22 mmol) prepared as described in example 290 employing the procedure described in example 80 was followed by chromatography on silica eluting with ethyl acetate/hexane (4:1). Crystallisation from ethyl acetate/hexane gave phenol (226) (28 mg, 31%) as an orange/yellow powder, mp 290–295° C. 1H NMR δ [(CD3)2SO] 11.04 (br s, 1H), 9.30 (s, 1H), 8.40 (d, J=2.4 Hz, 1H), 7.79 (s, 1H), 7.63 (m, 2H), 7.55 (d, J=8.8 Hz, 1H), 7.47 (m, 3H), 7.11 (dd, J=8.8, 2.4 Hz, 1H), 5.00 (d, J=5.4 Hz, 1H), 4.86 (t, J=5.4 Hz, 1H), 4.51 (dd, J=3.8, 14.9 Hz, 1H), 4.35 (dd, J=7.5, 14.9 Hz, 1H), 3.89 (m, 1H), 3.41 (m, 2H). Found: C, 67.94; H, 4.69; N, 6.50. C23H18N2O5.1/4H2O requires: C, 67.89; H, 4.58; N, 6.88.

Workup

  1. customCrystallisation from ethyl acetate/hexane

Sources & evidence

ORD record
ord-b5ff531db69c462a869d3c4a2037c1a7
Source dataset
uspto-grants-2006_08
Patent number
US07094798B1

Reaction notes

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