反应详情

A mixture of 10.37 g (0.03 mol) of ethyl (S)-8-chloro-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate, 35 ml of hydroxymethyl-cyclopropane and 0.5 g of potassium cyanide is stirred at 125° for 12 hours, during this time three 2-3 ml portions of the solvent being distilled off by the application of a slight vacuum. The mixture is subsequently evaporated in vacuo, the residue is partitioned between chloroform and water, the chloroform solution is washed successively with water and saturated sodium chloride solution, dried over magnesium sulphate and evaporated. The residue obtained is recrystallized from ethyl acetate, there being obtained cyclopropylmethyl (S)-8-chloro-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate of melting point 195°-196 °.

1. distillationbeing distilled off by the application of a slight vacuum
2. customThe mixture is subsequently evaporated in vacuo
3. customthe residue is partitioned between chloroform and water
4. washthe chloroform solution is washed successively with water and saturated sodium chloride solution
5. dry with materialdried over magnesium sulphate
6. customevaporated
7. customThe residue obtained
8. customis recrystallized from ethyl acetate, there