反应详情

5 g (14.5 mmol) of ethyl (S)-8-chloro-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate, 70 mg of powdered potassium cyanide and 20 ml of benzyl alcohol are stirred at 110° for 1 hour, evaporated to dryness and the residue is taken up in chloroform. The solution is washed with water, dried over magnesium sulphate and evaporated. By recrystallization from ethanol and ether there is obtained benzyl (S)-8-chloro-11,12,13,13a-tetrahydro-9-oxo-9H-imidazo[1,5-a]pyrrolo[2,1-c][1,4]benzodiazepine-1-carboxylate of melting point 141°-142°.

1. customevaporated to dryness
2. washThe solution is washed with water
3. dry with materialdried over magnesium sulphate
4. customevaporated
5. customBy recrystallization from ethanol and ether