HRID1157606
反应详情
EQUATION
反应方程式
REACTANTS
反应物
PRODUCTS
生成物
PROCEDURE
实验过程
The title compound was synthesized from 4-[2-(3-aminophenyl)pyrazolo[1,5-a]pyridin-3-yl]-N-(4-(methyloxy)-3-{4-[2-(methylsulfonyl)ethyl]-1-piperazinyl}phenyl)-2-pyrimidinamine using 2-thienylacetyl chloride as described in Example 10, Step E to give a light brown solid in 47% yield. 1H NMR (400 MHz, DMSO-D6) δ ppm 2.5 (m, 4H) 2.7 (m, 3H) 2.9 (m, 4H) 3.0 (s, 3H) 3.7 (s, 3H) 3.9 (s, 2H) 6.4 (d, J=5.1 Hz, 1H) 6.8 (d, J=9.1 Hz, 1H) 7.0 (d, J=4.6 Hz, 2H) 7.1 (t, J=6.6 Hz, 1H) 7.3 (m, 3H) 7.4 (d, J=10.4 Hz, 1H) 7.4 (m, 2H) 7.7 (d, J=8.1 Hz, 1H) 7.9 (s, 1H) 8.2 (d, J=5.5 Hz, 1H) 8.8 (d, J=7.0 Hz, 1H) 9.3 (s, 1H) 10.3 (s, 1H). ES-LC/MS m/z 723 [M+H]+.
WORKUP
后处理
- customto give a light brown solid in 47% yield