反应详情

The title compound was prepared by treating 2,2,2-trifluoro-N-(7-{[4-(2-{3-[(2-thienylacetyl)amino]phenyl}pyrazolo[1,5-a]pyridin-3-yl)-2-pyrimidinyl]amino}-1,2,3,4-tetrahydro-2-naphthalenyl)acetamide (60 mg, 0.09 mmol) with LiOH in MeOH as described in Example 54, Step D. Purification yielded 50 mg (51%) of the desired amine. 1H NMR (400 MHz, DMSO-d6) δ 10.32 (s, 1H), 9.34 (s, 1H), 8.80 (d, J=6.8 Hz, 1H), 8.46 (d, J=8.8 Hz, 1H), 8.18 (d, J=5.4 Hz, 1H), 7.86 (s, 1H), 7.72 (d, J=8.1 Hz, 1H), 7.48-7.34 (m, 4H), 7.24 (d, J=7.6 Hz, 1H), 7.09 (t, J=6.7 Hz, 1H), 6.95-6.89 (m, 3H), 6.41 (d, J=5.2 Hz, 1H), 3.85 (s, 2H), 2.96 (m, 1H), 2.79-2.60 (m, 3H), 2.41-2.31 (m, 1H), 1.90-1.74 (m, 3H), 1.46-1.33 (m, 1H). ES-LC/MS m/z=572 [M+H]+.

1. customThe title compound was prepared
2. customPurification