反应详情

In a 250 mL round-bottomed flask was added 2-amino-6-nonylpyrimidin-4(1H)-one (1.88 g, 7.92 mmol) in Pyridine 50 mL to give a white suspension. The mixture was heated to 50 deg/C. 11,12-bis(8-isocyanatooctyl)docosane (2.327 g, 3.77 mmol) was dissolved in 5-10 mL of pyridine and added all at once to the mixture. The reaction was heated to 75 deg/C. and stirred for 24 h. The pyridine was removed and the residue was taken up in chloroform and the viscous solution was dripped into a rapidly stirring solution (500 mL) of MeOH upon which a white solid formed. The solution was decanted off and the residue was taken up in MeOH (10 ml) and rapidly stirred for 1 h. The product was collected by vacuum filtration dried under vacuum to give 4 g of 1,1′-(9,10-didecyloctadecane-1,18-diyl)bis(3-(6-nonyl-4-oxo-1,4-dihydropyrimidin-2-yl)urea).

1. customto give a white suspension
2. temperatureThe mixture was heated to 50 deg/C
3. additionadded all at once to the mixture
4. temperatureThe reaction was heated to 75 deg/C
5. customThe pyridine was removed
6. customformed
7. customThe solution was decanted off
8. stirringrapidly stirred for 1 h
9. filtrationThe product was collected by vacuum filtration
10. customdried under vacuum