3-(Trifluoromethyl)phenyl isocyanate → N-[4-(3-amino-1-methyl-1H-pyrazolo[3,4-c]pyridin-4-yl)phenyl]-N'-[3-(trifluoromethyl)phenyl]urea
反応式
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[N:12][CH:11]=[C:10]3[N:14]([CH3:18])[N:15]=[C:16]([NH2:17])[C:9]=23)=[CH:4][CH:3]=1.[N:19]([C:22]1[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([F:31])([F:30])[F:29])[CH:23]=1)=[C:20]=[O:21].FC1C=CC(C)=CC=1N=C=O>>[NH2:17][C:16]1[C:9]2[C:10](=[CH:11][N:12]=[CH:13][C:8]=2[C:5]2[CH:4]=[CH:3][C:2]([NH:1][C:20]([NH:19][C:22]3[CH:27]=[CH:26][CH:25]=[C:24]([C:28]([F:29])([F:30])[F:31])[CH:23]=3)=[O:21])=[CH:7][CH:6]=2)[N:14]([CH3:18])[N:15]=1参加物
4
実験手順
The title compound was prepared using the procedure described in Example 1E using the product from Example 6A and 1-isocyanato-3-trifluoromethyl-benzene instead of the product from Example 1D and 1-fluoro-2-isocyanato-4-methyl-benzene. MS (ESI(+)) m/e 427 (M+H)+; 1H NMR (500 MHz, DMSO-D6) δ ppm 3.92 (s, 3H) 4.66 (s, 2H) 7.33 (d, J=7.49 Hz, 1H) 7.48 (d, J=8.73 Hz, 2H) 7.53 (t, J=7.95 Hz, 1H) 7.61 (d, J=9.05 Hz, 1H) 7.65 (d, J=8.73 Hz, 2H) 7.95 (s, 1H) 8.04 (s, 1H) 8.87 (s, 1H) 8.98 (s, 1H) 9.10 (s, 1H).
出典と根拠
- ORDレコード
- ord-2c05664a3e014f2f8824f27153493171
- 出典データセット
- uspto-grants-2010_10
- 特許番号
- US07812166B2
反応ノート
読み込み中…