反应详情

Under Ar atmosphere, to a solution of ethyl isobutyrate (18.2 g, 156.6 mmol) and DMPU (1 mL) in THF (30 mL) was added LDA (80 mL, 2 M in heptanes, 160 mmol) at −78° C. The mixture was stirred for 30 min. A solution of bis-(4-bromomethylphenyl)-methanone (21.1 g, 57.3 mmol) in THF (100 mL) was added dropwise. The reaction mixture was allowed to stir overnight, gradually warming to room temperature. Most of the THF (120 mL) was removed under reduced presure. The mixture was hydrolyzed with 6 N aqueous HCl (30 mL), water (170 g), and saturated NH4Cl solution(200 mL). The solution was extracted with ethyl acetate (200 mL, 2×100 mL). The organic layers were washed with half-saturated NaCl solution (100 mL), dried over MgSO4, and concentrated under vacuum to give a crude oil (35.8 g). Purification by column chromatography on silica (800 g) using hexanes/ethyl acetate (10:1) as eluent afforded 3-{4-[4-(2-ethoxycarbonyl-2-methylpropyl)-benzoyl]-phenyl}-2,2-dimethylpropionic acid ethyl ester (8.50 g, 34%) as a colorless oil. 1H NMR (300 MHz, CDCl3/TMS): δ (ppm): 7.73 (d, 4 H, J=8.1 Hz), 7.26 (d, 4 H, J=8.1 Hz), 4.19-4.11 (m, 4 H), 2.97 (s, 4H), 1.29-1.15 (m, 18 H). 13C NMR (75 MHz, CDCl3=77.00 ppm): δ (ppm): 195.8, 176.8, 142.9, 135.8, 129.9, 129.7, 60.4, 46.0, 43.4, 24.8, 14.1. HRMS (LSIMS, nba): Calcd for C27H35O5 (M+H): 439.2484, found: 439.2487.

1. stirringto stir overnight
2. customMost of the THF (120 mL) was removed
3. extractionThe solution was extracted with ethyl acetate (200 mL, 2×100 mL)
4. washThe organic layers were washed with half-saturated NaCl solution (100 mL)
5. dry with materialdried over MgSO4
6. concentrationconcentrated under vacuum
7. customto give a crude oil (35.8 g)
8. customPurification by column chromatography on silica (800 g)