反应详情

The title compound was prepared according to the procedure of Example 112, Step 1, starting from 7-(bromomethyl)-5-nitro-1-benzofuran (120 mg, 70 mol %, 0.39 mmol; Intermediate 64) and 2-methylpiperazine (196 mg, 1.95 mmol). The crude product was purified by flash chromatography (eluent: 4% MeOH, 1% NEt3 in DCM). The title compound (102 mg, 87%) was obtained as a light yellow sticky oil. HPLC 99%, RT=1.60 min (System A; 5-60% MeCN over 3 min), 100%, RT=1.40 min (System B; 5-60% MeCN over 3 min). MS (ESI+) for C14H17N3O3 m/z 276 (M+H)+.

1. customThe title compound was prepared
2. customThe crude product was purified by flash chromatography (eluent: 4% MeOH, 1% NEt3 in DCM)