反应详情

Methyl(2R)-4-((4-chlorophenyl)amino)-2-cyclohexyl-4-oxobutanoate (0.29 g) obtained in Example 5a) and 1 N sodium hydroxide (1.0 ml) were dissolved in methanol (12 ml) and THF (3 ml), and mixed at room temperature for 1 hour. Then, the reaction solution was concentrated under reduced pressure, acidified by adding 1 N hydrochloric acid to the concentrated solution and extracted with ethyl acetate. The extract was dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure to obtain the title compound as pale brown powder (0.28 g, quantitative).

1. concentrationThen, the reaction solution was concentrated under reduced pressure
2. additionby adding 1 N hydrochloric acid to the concentrated solution
3. extractionextracted with ethyl acetate
4. dry with materialThe extract was dried over anhydrous sodium sulfate
5. distillationthe solvent was distilled off under reduced pressure