反应详情

Following the procedure described for compound N-(6-(6-chloro-5-(4-(2-hydroxypropan-2-yl)phenylsulfonamido)pyridin-3-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide (Example 35), N-(6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-b]pyridazin-2-yl)acetamide (122 mg, 404 μmol) (Example 35, Step 3) was reacted with N-(5-bromo-2-chloropyridin-3-yl)morpholine-4-sulfonamide from Step 1 (120 mg, 336 μmol) to afford the title compound as a light green solid (40 mg, 26% yield). MS (ESI positive ion) m/z: 452 (M+1). 1H NMR (400 MHz, DMSO-d6): δ ppm 2.12 (s, 3H), 3.12-3.18 (m, 4H), 3.60-3.68 (m, 4H), 7.86 (d, J=9.39 Hz, 1H), 8.14 (d, J=9.39 Hz, 1H), 8.33 (s, 1H), 8.54 (d, J=2.15 Hz, 1H), 8.90 (s, 1H), 10.14 (s, 1H), 10.97 (s, 1H).