HRID1162945

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：O=C1O[C@H](CO)CN1c1ccc2cc(-c3ccccc3C(F)(F)F)[nH]c(=O)c2c1

HCID11853672

未命名化合物

结构：O=C(O)C(COCc1ccccc1)(COCc1ccccc1)COCc1ccccc1

HCID57557937

未命名化合物

HCID178418361

未命名化合物

PRODUCTS

生成物

结构：O=C1O[C@H](COC(=O)C(CO)(CO)CO)CN1c1ccc2cc(-c3ccccc3C(F)(F)F)[nH]c(=O)c2c1

HCID57557884

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

PROCEDURE

实验过程

Condensation was carried out by a method similar to that of Example 3-1 using 3-benzyloxy-2,2-bis(benzyloxymethyl)propionic acid obtained in Step B instead of Boc-Sar-OH and 7-((S)-5-hydroxymethyl-2-oxooxazolidin-3-yl)-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one obtained in Step B of Example 1-13 instead of 7-((R)-5-hydroxymethyl-2-oxooxazolidin-3-yl)-3-(2-trifluoromethylphenyl)-2H-isoquinolin-1-one obtained in Step B of Example 1-14, and deprotection was carried out by a method similar to that of Example 1-36 using a 10% Pd—C catalyst in a hydrogen atmosphere to synthesize the title compound.

WORKUP

后处理

customCondensation

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d54666c7a719477380ffabff6b1493dc
来源数据集: uspto-grants-2010_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07820693B2
来源说明: uspto-grants-2010_10

反应 SMILES

C([O:8][CH2:9][C:10]([CH2:23][O:24]CC1C=CC=CC=1)([CH2:14][O:15]CC1C=CC=CC=1)[C:11](O)=[O:12])C1C=CC=CC=1.[OH:32][CH2:33][C@H:34]1[O:38][C:37](=[O:39])[N:36]([C:40]2[CH:49]=[C:48]3[C:43]([CH:44]=[C:45]([C:51]4[CH:56]=[CH:55][CH:54]=[CH:53][C:52]=4[C:57]([F:60])([F:59])[F:58])[NH:46][C:47]3=[O:50])=[CH:42][CH:41]=2)[CH2:35]1.[H][H]>[Pd]>[OH:12][CH2:11][C:10]([CH2:23][OH:24])([CH2:14][OH:15])[C:9]([O:32][CH2:33][C@H:34]1[O:38][C:37](=[O:39])[N:36]([C:40]2[CH:49]=[C:48]3[C:43]([CH:44]=[C:45]([C:51]4[CH:56]=[CH:55][CH:54]=[CH:53][C:52]=4[C:57]([F:59])([F:58])[F:60])[NH:46][C:47]3=[O:50])=[CH:42][CH:41]=2)[CH2:35]1)=[O:8]