反应详情

Intermediate 2,5-dimethyl-4-(4′-methoxy-2′-methyl-3′-iso-propylbenzyl)phenol was prepared from 2,5-dimethyl-4-triisopropylsilanyloxy-benzaldehyde and 1-bromo-4-methoxy-2-methyl-3-iso-propylbenzene according to the procedure described in G. Chiellini et al. Biorg. Med. Chem. Lett. 2000, 10, 2607 and transformed into the title compound by the procedure described for the synthesis of compound 7: 1H NMR (300 MHz, DMSO-d6): δ6.93 (s, 1 H), 6.75 (d, J=8.4 Hz, 1 H), 6.65 (d, J=8.4 Hz, 1 H), 6.64 (s, 1 H), 4.09 (d, J=9.9 Hz, 2 H), 3.79 (s, 2 H), 3.77 (s, 3 H), 3.34 (m, 1 H), 2.22 (s, 3 H), 2.20 (s, 3 H), 2.10 (s, 3 H), 1.31 (d, J=7.2 Hz, 6 H); LC-MS m/z=391 [C21H29O5P−H]−.