反应详情

温度

0 °C

17.3 g 2-Chloro-4-methyl-benzonitrile were dissolved in 50 ml tetrachloromethane and heated to reflux. A mixture of 24.3 g N-bromosuccinimide and 7.48 g 2,2′-azobis(2-methylpropionitrile) were added in five portions over a period of one hour. The reaction mixture was heated under reflux for additional three hours. The cooled reaction mixture was then filtered through a celite pad. The filtrate was washed with 100 ml saturated NaHCO3 solution, dried over MgSO4 and the solvent was removed in vacuo. The resulting residue was dissolved in 200 ml tetrahydrofuran and cooled in an ice bath to 0° C. 88.0 ml diethyl phosphite were added, followed by the addition of 117.0 ml N,N-diisopropylethylamine. The cooling bath was removed and the reaction mixture stirred at room temperature for four hours. The reaction mixture was poured in 400 ml 50% NaHCO3 solution and extracted with 400 ml diethylether. The organic layer was separated and washed with 200 ml 50% NaHCO3 solution and 200 ml water and then dried over MgSO4. The solvent was removed in vacuo. The resulting residue was purified on silica gel with the eluent n-heptane:ethyl acetate=19:1 to obtain 13.0 g 4-Bromomethyl-2-chloro-benzonitrile as a solid.

1. temperatureheated to reflux
2. additionwere added in five portions over a period of one hour
3. temperatureThe reaction mixture was heated
4. temperatureunder reflux for additional three hours
5. customThe cooled reaction mixture
6. filtrationwas then filtered through a celite pad
7. washThe filtrate was washed with 100 ml saturated NaHCO3 solution
8. dry with materialdried over MgSO4
9. customthe solvent was removed in vacuo
10. dissolutionThe resulting residue was dissolved in 200 ml tetrahydrofuran
11. addition88.0 ml diethyl phosphite were added
12. additionfollowed by the addition of 117.0 ml N,N-diisopropylethylamine
13. customThe cooling bath was removed
14. additionThe reaction mixture was poured in 400 ml 50% NaHCO3 solution
15. extractionextracted with 400 ml diethylether
16. customThe organic layer was separated
17. washwashed with 200 ml 50% NaHCO3 solution and 200 ml water
18. dry with materialdried over MgSO4
19. customThe solvent was removed in vacuo
20. customThe resulting residue was purified on silica gel with the eluent n-heptane