反应详情

A solution of 4-(3-tert-butyl-5-phenoxycarbonylamino-pyrazol-1-yl)benzoic acid methyl ester (470 mg, 1.19 mmol) and 2-fluoro-4-(2-methyl-pyridin-4-yloxy)-phenylamine (260.69 mg, 1.19 mmol) was stirred at 40° C. overnight. The mixture was cooled to room temperature, and then evaporated at reduced pressure. The residue was purified by MPLC (eluting with 50:50 EtOAc/hexane) to afford the title compound (407 mg, 66%). 1H-NMR (DMSO-d6) δ 8.94 (s, 2H), 8.30 (d, J=5.7 Hz, 1H), 8.09 (m, 3H), 7.71 (d, J=5.7 Hz, 2H), 7.20 (d, J=14.7, 1H), 6.94 (d, J=5.4 Hz, 1H), 6.77 (d, J=2.7 Hz, 1H), 6.72 (d, J=5.4 Hz, 1H), 6.42 (s, 1H), 3.87 (s, 3H), 2.38 (s, 3H), 1.27 (s, 9H); MS LC-MS [M+H]+=518.2, RT=2.94 min.

1. customevaporated at reduced pressure
2. customThe residue was purified by MPLC (eluting with 50:50 EtOAc/hexane)