反应详情

The title compound is prepared by following Method C, using 4-cyclohexylmethoxy-benzoic acid (Crooks, S. L.; Merrill, B. A.; Wightman, P. D. WO 9603983 A1.) (0.46 g, 1.98 mmol), oxalyl chloride (0.66 mL, 7.62 mmol) and isomer-1 of N*2*-methyl-N*2*-(1-methyl-pyrrolidin-3-yl)-benzothiazole-2,6-diamine (0.40 g, 1.51 mmol) to afford 4-cyclohexylmethoxy-N-{2-[methyl-(1-methyl-pyrrolidin-3-yl)-amino]-benzothiazol-6-yl}-benzamide (0.083 11%). The material is dissolved in EtOH and treated with 1.0 M HCl in EtOH (0.17 mL). Heptane is added and the resulting solid is collected to give 0.052 g (59%) of the hydrochloride salt. LC/MS: Retention time=5.38 min; (m/z): calcd for C27H34N4O2S (M+H)+: 479.7; found: 479.3.