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HRID1177114

反应详情

EQUATION

反应方程式

HRID 1177114 的结构方程式

REACTANTS

反应物

3
结构：COC(=O)c1cc(O)c2c(c1)OC(C)(C)C2
HCID25067323

Methyl 4-hydroxy-2,2-dimethyl-2,3-dihydro-1-benzofuran-6-carboxylate

C12H14O4

结构：CC(C)(C)OC(=O)c1c(F)cc(Br)cc1F
HCID53432588

tert-Butyl 4-bromo-2,6-difluorobenzoate

C11H11BrF2O2

结构：COC(=O)c1cc(Oc2ccc(C(=O)N3CCC3)cc2)c2c(c1)OC(C)(C)C2
HCID59560251

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)c1cc(Oc2cc(F)c(C(=O)OC(C)(C)C)c(F)c2)c2c(c1)OC(C)(C)C2
HCID59560426

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in a similar manner as described for Intermediate 35b, from 4-hydroxy-2,2-dimethyl-2,3-dihydro-benzofuran-6-carboxylic acid methyl ester (3e) and 4-bromo-2,6-difluoro-benzoic acid tert-butyl ester. 1H NMR (400 MHz, CDCl3) δ 7.29 (s, 1 H) 7.23 (s, 1 H) 6.48 (d, J=8.84 Hz, 2 H) 3.89 (s, 3 H) 2.88 (s, 2 H) 1.59 (s, 9 H) 1.49 (s, 6 H); LCMS for C23H24F2O6 m/z 457.20 (M+Na)+.