4-(4-Dimethylcarbamoyl-3-fluoro-phenoxy)-2,2-dimethyl-2,3-dihydro-benzofuran-6-carboxylic acid methyl ester → 4-(4-Dimethylcarbamoyl-3-fluoro-phenoxy)-2,2-dimethyl-2,3-dihydro-benzofuran-6-carboxylic acid
Reaction equation
CS(C1C=CC(OC2C3CC(C)(C)OC=3C=C(C(O)=O)C=2)=CC=1)(=O)=O.C[O:27][C:28]([C:30]1[CH:40]=[C:39]([O:41][C:42]2[CH:47]=[CH:46][C:45]([C:48](=[O:52])[N:49]([CH3:51])[CH3:50])=[C:44]([F:53])[CH:43]=2)[C:33]2[CH2:34][C:35]([CH3:38])([CH3:37])[O:36][C:32]=2[CH:31]=1)=[O:29]>>[CH3:51][N:49]([CH3:50])[C:48]([C:45]1[CH:46]=[CH:47][C:42]([O:41][C:39]2[C:33]3[CH2:34][C:35]([CH3:38])([CH3:37])[O:36][C:32]=3[CH:31]=[C:30]([C:28]([OH:29])=[O:27])[CH:40]=2)=[CH:43][C:44]=1[F:53])=[O:52]Participants
3
Reactant 2
Product 1
Procedure
The title compound was prepared in a similar manner as described for Intermediate 15a, from 4-(4-dimethylcarbamoyl-3-fluoro-phenoxy)-2,2-dimethyl-2,3-dihydro-benzofuran-6-carboxylic acid methyl ester (142a). 1H NMR (400 MHz, CDCl3)) δ 7.40 (t, J=7.96 Hz, 1 H) 7.27-7.33 (m, 2 H) 6.80 (dd, J=8.34, 2.02 Hz, 1 H) 6.70 (dd, J=10.61, 2.27 Hz, 1 H) 3.10-3.18 (m, 3 H) 3.00 (br. s., 3 H) 2.92 (s, 2 H) 1.49 (s, 6 H); LCMS for C20H20FNO5 m/z 374.00 (M+H).
Sources & evidence
- ORD record
- ord-ea2e4c0f25064d5dac7cc3785a8bea5d
- Source dataset
- uspto-grants-2010_11
- Patent number
- US07842713B2
Reaction notes
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