反应详情

2-(4-(1,3-Dioxan-2-yl)-2-fluorophenyl)-6-(1-(pyridine-2-yl)cyclopropyl)benzo[d]-thiazole (38 mg, 0.088 mmol) was stirred in THF (1 mL) and 5 N HCl (aq., 0.2 mL) at 50° C. for 2 h. The reaction mixture was cooled to RT, neutralized with satd. NaHCO3, and extracted with EtOAc three times. The organic extracts were dried (MgSO4) and concentrated to give 3-fluoro-4-(6-(1-(pyridine-2-yl)cyclopropyl)benzo[d]thiazol-2-yl)benzaldehyde as a yellow solid. MS (ESI) m/z: Calculated: 374.1; Observed: 375.0 (M++1).

1. extractionNaHCO3, and extracted with EtOAc three times
2. dry with materialThe organic extracts were dried (MgSO4)
3. concentrationconcentrated