反应详情

8-{4-[2-(6-methoxy-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-6-chloro-quinoline was prepared by generally following the procedure outlined in example 9, step 6, starting from 2-(6-methoxy-1-benzofuran-3-yl)ethyl iodide (301 mg, 1 mmol) and 6-chloro-8-piperazino quinoline (247 mg, 1 mmol). The product was purified by silica-gel column chromatography by initially eluting it with 80% ethyl acetate:hexane and then with 5% methanol:ethyl acetate, yielding a brown oil Yield: 140 mg (33%); (M+H): 422; 1HNMR (400 MHz, CDCl3):δ 8.86˜8.68 (dd, J1=1.8 Hz, J2=1.8 Hz, 1H); 8.02˜7.99 (dd, J1=1.8 Hz, J2=1.8 Hz, 1H); 7.45˜6.63 (m, 7H); 3.9 (s, 3H); 3.65˜2.71 (m, 12H).

1. customThe product was purified by silica-gel column chromatography
2. washby initially eluting it with 80% ethyl acetate