反应详情

8-{4-[2-(7-methoxy-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-6-chloro-quinoline was prepared by generally following the procedure outlined in example 18, step 3, starting from 2-(7-methoxy-1-benzofuran-3-yl)ethyl iodide (301 mg, 1 mmol) and 6-chloro-8-piperazino quinoline (247 mg, 1 mmol). The product was purified by silica-gel column chromatography by eluting it initially with 80% ethyl acetate:hexane and then with 5% methanol:ethyl acetate. A HCl salt was prepared, yielding a green spongy solid. mp 248° C.; Yield: 320 mg (69%); (M+H): 424; 1H NMR δ 11.8 (bs, 1H), 9.0 (d, 1H), 8.5 (d, 1H), 8.0 (s, 1H), 7.8-7.0 (m, 5H), 6.8 (d, 1H), 4.2 (d, 2H), 3.9 (s, 3H), 3.7-3.2 (m, 10H).

1. customThe product was purified by silica-gel column chromatography
2. washby eluting it initially with 80% ethyl acetate
3. customyielding a green spongy solid