反应详情

8-{4-[2-(5-methoxy-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-6-chloro-quinoline was prepared by generally following the procedure outlined in example 21, step 6, starting from 2-(5-methoxy-1-benzofuran-3-yl)ethyl iodide (301 mg, 1 mmol) and 6-chloro-8-piperazino quinoline (247 mg, 1 mmol). The product was purified by silica-gel column chromatography by eluting it initially with 80% ethyl acetate:hexane and then with 5% methanol:ethyl acetate, yield a brown solid. MP: 72° C.; Yield: 130 mg (30%); (M+H): 422; 1HNMR (400 MHz, CDCl3): δ□8.86˜8.84 (dd, J1=1.7 Hz, J2=1.7 Hz, 1H); 8.05˜8.02 (dd, J1=1.7 Hz,J2=1.7 Hz, 1H); 7.60˜6.88 (m, 7H); 3.86 (s, 3H); 3.69˜2.57 (m, 12H).

1. customThe product was purified by silica-gel column chromatography
2. washby eluting it initially with 80% ethyl acetate
3. customhexane and then with 5% methanol:ethyl acetate, yield a brown solid