反应详情

8-{4-[2-(5-methoxy-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-6-methyl-quinoline was prepared by generally following the procedure outlined in example 21, step 6, starting from 2-(5-methoxy-1-benzofuran-3-yl)ethyl iodide (301 mg, 1 mmol) and 6-methyl-8-piperazino quinoline (227 mg, 1 mmol). The product was purified by silica-gel column chromatography by eluting it initially with 80% ethyl acetate:hexane and then with 5% methanol:ethyl acetate, yielding a brown oil. Yield: 150 mg (37%); (M+H): 402; 1HNMR (400 MHz, CDCl3): δ 8.82˜8.73 (dd, J1=1.7 Hz, J2=1.7 Hz, 1H); 8.03-802 (dd, J1=1.7 Hz, J2=1.7 Hz, 1H), 8.00˜6.88 (m, 7H); 3.87 (s, 3H) 3.49˜2.57 (m, 12H), 2.5 (s, 3H).

1. customThe product was purified by silica-gel column chromatography
2. washby eluting it initially with 80% ethyl acetate
3. customhexane and then with 5% methanol:ethyl acetate, yielding a brown oil