反应详情

8-{4-[2-(5-methoxy-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-6-isopropyl-quinoline was prepared by generally following the procedure outlined in example 21, step 6, starting from 2-(5-methoxy-1-benzofuran-3-yl)ethyl iodide (301 mg, 1 mmol) and 6-isopropyl-8-piperazino quinoline (255 mg, 1 mmol). The product was purified by silica-gel column chromatography by eluting it initially with 80% ethyl acetate:hexane and then with 5% methanol:ethyl acetate, yielding a brown oil. Yield: 90 mg (20%); (M+H): 430; 1HNMR (400 MHz, CDCl3): δ 8.83˜8.12 (dd, J1=1.8 Hz, J2=1.8 Hz, 1H), 8.08˜804 (dd,J1=1.8 Hz, J2=1.8 Hz, 1H), 7.75˜6.70 (m, 7H), 3.84 (s, 3H), 3.50˜2.86 (m, 12H), 2.90˜3.01 (m, 1H), 1.34˜1.33 (d, 7 Hz, 6H).

1. customThe product was purified by silica-gel column chromatography
2. washby eluting it initially with 80% ethyl acetate
3. customhexane and then with 5% methanol:ethyl acetate, yielding a brown oil