反应详情

8-{4-[2-(5-methoxy-1-benzofuran-3-yl)ethyl]-1-piperazinyl}-6-methoxy-quinoline was prepared by generally following the procedure outlined in example 21, step 6, starting from 2-(5-methoxy-1-benzofuran-3-yl)ethyl iodide (301 mg, 1 mmol) and 6-methoxyl-8-piperazino quinoline (243 mg, 1 mmol). The product was purified by silica-gel column chromatography by eluting it initially with 80% ethyl acetate:hexane and then with 5% methanol:ethyl acetate, yielding a brown oil. Yield: 90 mg, (21%); (M+H): 418; 1HNMR (400 MHZ, CDCl3): δ 8.73˜8.71 (dd, J1=1.7 Hz, J2=1.7 Hz, 1H) 8.03˜8.00 (dd, J1=1.7 Hz, J2=1.7 Hz, 1H), 7.50˜6.71 (m, 7H); 3.91 (s, 3H), 3.87 (s, 3H), 3.55˜2.82 (12H).

1. customThe product was purified by silica-gel column chromatography
2. washby eluting it initially with 80% ethyl acetate
3. customhexane and then with 5% methanol:ethyl acetate, yielding a brown oil