反应详情

2.7 ml (42 mmoles) of methanesulphonic acid were added to a suspension de 6 g (21 mmoles) of the 3-(2-hydroxyethyl)-5-[1,2,4]triazol-1-ylmethyl-1H-indol-2-carboxylic acid in 120 ml of methanol. The mixture was left under stirring at reflux temperature for 3 hours. The solvent was evaporated to dryness under reduced pressure, the residue dissolved with 20 ml of a saturated bicarbonate solution and extracted 3 times with ethyl acetate. The combined organic phases were dried and evaporated to dryness, and the evaporated solid recrystallised from isopropyl alcohol/heptane to give 5.9 g (93%) of the title ester as a yellow crystalline solid.

1. waitThe mixture was left
2. temperatureat reflux temperature for 3 hours
3. customThe solvent was evaporated to dryness under reduced pressure
4. dissolutionthe residue dissolved with 20 ml of a saturated bicarbonate solution
5. extractionextracted 3 times with ethyl acetate
6. customThe combined organic phases were dried
7. customevaporated to dryness
8. customthe evaporated solid recrystallised from isopropyl alcohol/heptane