反应详情

[1-(2,6-Difluorobenzyl)cyclobutyl]methyl(1S)-5-{[(methylamino)carbonyl]amino}-1-(oxo{[(1R)-1-phenylethyl]amino}acetyl)pentylcarbamate was prepared as in example 9j except that [1-(2,6-difluorobenzyl)cyclobutyl]methyl(1S)-1-(1-hydroxy-2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)-5-{[(methylamino)carbonyl]amino}pentylcarbamate was substituted for (1-benzylcyclohexyl)methyl(1S)-1-(1-hydroxy-2-oxo-2-{[(1R)-1-phenylethyl]amino}ethyl)-5-[(4-morpholinylcarbonyl)amino]pentylcarbamate. 1H NMR (300 MHz, DMSO-d6) δ 9.19 (m, 1H), 7.58 (m, 1H), 7.05-7.43 (m, 8H), 5.86 (m, 1H), 5.65 (m, 1H), 4.98 (m, 1H), 4.76 (m, 1H), 3.95 (m, 2H). 3.25 under water peak (m, 3H), 2.96 (m, 2H), 2.78 (s, 2H), 1.60-1.90 (m, 6H), 1.25-1.50 (m, 9H). ES-LCMS m/z 571 (M−H).