反应详情

To a solution of 4-chloro-N-{3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl}-2-nitrobenzamide (11.9 mmol, 5.0 g) in ethanol was added tin(II) chloride dihydrate (35.8 mmol, 8.1 g). The resulting mixture was heated to reflux for 4 h and then concentrated by rotary evaporation. The residue was dissolved in ethyl acetate and was washed with potassium sodium tartrate tetrahydrate solution repeatedly. The crude product was first extracted with 2N HCl, then made basic by adding NaOH with ice cooling. The combined basic aqueous solution was extracted with DCM. The organic extraction was washed with brine, dried and concentrated giving the product (4.5 g, 97%). 1H NMR (DMSO-D6): δ 1.67 (4H, m), 2.48 (4H, m), 2.81 (2H, t, J=5.8 Hz), 3.75 (3H, s), 4.10 (2H, t, J=5.8 Hz), 7.02 (1H, d, J=6.2 Hz), 7.10 (1H, d, J=8.6 Hz), 7.16 (1H, s), 7.62 (1H, d, J=8.6 Hz), 7.80 (1H, s), 8.17 (1H, d, 8.6 Hz), 8.35 (1H, s). LCMS m/z=390 (m+H+).

1. temperatureThe resulting mixture was heated
2. temperatureto reflux for 4 h
3. concentrationconcentrated by rotary evaporation
4. dissolutionThe residue was dissolved in ethyl acetate
5. washwas washed with potassium sodium tartrate tetrahydrate solution repeatedly
6. extractionThe crude product was first extracted with 2N HCl
7. additionby adding NaOH with ice cooling
8. extractionThe combined basic aqueous solution was extracted with DCM
9. extractionThe organic extraction
10. washwas washed with brine
11. customdried
12. concentrationconcentrated