反应详情

温度

100 °C

N-(1-Chloroisoquinolin-5-yl)-N′-(4-trifluoromethylbenzyl)urea (Example 69; 60 mg) was suspended in ethanol (5 ml). Ethanolic dimethylamine (33%, 2 ml) was added and the mixture heated to 100° C. in a sealed tube for 16 hours after which time TLC indicated complete reaction. The reaction mixture was evaporated and the residue purified by preparative thin layer chromatography (5% methanol-dichloromethane eluant) to give the title compound (20 mg). m/z (ES+) 389 (M+H)+.

1. customreaction
2. customThe reaction mixture was evaporated
3. customthe residue purified by preparative thin layer chromatography (5% methanol-dichloromethane eluant)