反应详情

The following compounds were prepared based on the above general procedures: For example, compound (S)-7-chloro-3-(2-chlorobenzyl)-5-(3-methyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl)-1H-benzo[e][1,4]diazepin-2(3H)-one (IV-2) was prepared by using (S)-2-chlorophenylalanine in place of (R)-2-chlorophenylalanineL Optical rotation data: C=1.0 (CHCl3), [α]D=−62°; MS (m/z): 465.1, 467.1; 1H NMR (d6-DMSO) δ 11.08 (s, 1H), 10.75 (s, 1H), 7.63 (m, 1H), 7.53 (m, 1H), 7.40 (m, 1H), 7.33-7.23 (m, 4H), 7.13 (m, 1H), 6.96 (m, 1H), 6.89 (m, 1H) 3.76 (m, 1H), 3.56-3.42 (m, 2H), 3.26 (s, 1H);

1. customThe following compounds were prepared